Related Experiment Video
Updated: Aug 11, 2026
A Contusive Model of Unilateral Cervical Spinal Cord Injury Using the Infinite Horizon Impactor
Published on: July 24, 2012
[The early protective effects of basic fibroblast growth factor on acute spinal cord injury in rats]
1Department of Orthopedic Surgery, Tongji Hospital, Tongji Medical University, Wuhan, Hubei, P. R. China 430030.
Objective:
To study the early protective effects of basic fibroblast growth factor(bFGF) on the experimental acute spinal cord injury.
Methods:
Thirty-four SD rats were randomly divided into three groups, and were subjected to contusion of thoracolumbar spinal cord. A thin plastic tube was placed in subarachnoid space below the injury level for perfusion. The bFGF-treated rats were received 20 microliters bFGF(containing bFGF 100 U) at once, 30 min, 1, 2, 3, 4, 6, 12, 24 and 48 hours after injury, and an equal volume of normal saline was given to the control group at the same time. The injured spinal cord was detected by morphological observation and biochemical index after injury.
Results:
The degree of ionic disorder in bFGF-treated rats was significantly ameliorated and the contents of H2O were also markedly decreased. The morphological finding showed that the damages of gray and white matter in bFGF-treated rats were slighter than those of saline-treated rats.
Conclusion:
bFGF has some protective effects on the secondary lesion of early spinal cord injury in rats.
More Related Videos
09:56Promotion of Survival and Differentiation of Neural Stem Cells with Fibrin and Growth Factor Cocktails after Severe Spinal Cord Injury
Published on: July 27, 2014
11:57Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury
Published on: February 23, 2015