Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polymer/alginate amalgam for cartilage-tissue engineering.

E J Caterson1, W J Li, L J Nesti

  • 1Department of Orthopaedic Surgery, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA 19107, USA.

Annals of the New York Academy of Sciences
|June 26, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A sequence-based genome-wide association study for dominance effects on fertility traits in Holstein cattle.

Animal : an international journal of animal bioscience·2026
Same author

In Memory of John Mulliken: Caretaker of Patients and Educator of All.

The Journal of craniofacial surgery·2026
Same author

[Discussion on the revision of Warning Signs for Occupational Hazards in the Workplace (GBZ 155-2003)].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2026
Same author

[Ocular manifestations of Malan syndrome: a case report].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2026
Same author

The Use of O-Arm Imaging to Guide Zygomaticomaxillary Complex Fracture Reduction.

The Journal of craniofacial surgery·2025
Same author

[A retrospective study on an innovative modular surgical technique in laparoscopic total gastrectomy combined with spleen-preserving hilar lymphadenectomy].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2025
Same journal

Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin-1 in B Cells.

Annals of the New York Academy of Sciences·2026
Same journal

Global Trends in Light Pollution and Their Relationship With Socioeconomic Factors.

Annals of the New York Academy of Sciences·2026
Same journal

Wired for Corruption: Inter-Brain Synchrony Encodes Bribery-Related Value Information and Predicts Bribery Agreement.

Annals of the New York Academy of Sciences·2026
Same journal

LM-YOLO: A Lightweight Multi-Scale Enhanced Model for Forest Smoke Detection Using Unmanned Aerial Vehicles.

Annals of the New York Academy of Sciences·2026
Same journal

Polyrhythm Perception and Production: A Scoping Review.

Annals of the New York Academy of Sciences·2026
Same journal

DARTS-CNN-BiLSTM: Intelligent Fault Diagnosis for Computer Numerical Control Machine Tool Feed System.

Annals of the New York Academy of Sciences·2026
See all related articles

Mesenchymal stem cells (MSCs) show chondrogenic potential in PLA/alginate scaffolds with TGF-beta1. This novel system supports cartilage development and may be useful for tissue engineering and cartilage repair.

Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Tissue Engineering

Background:

  • Mesenchymal stem cells (MSCs) are multipotent cells suitable for tissue engineering.
  • Investigating MSC chondrogenesis in 3D scaffolds is crucial for cartilage repair applications.

Purpose of the Study:

  • To characterize the chondrogenic potential of human MSCs in PLA/alginate scaffolds.
  • To evaluate the role of TGF-beta1 in promoting MSC chondrogenesis within 3D constructs.

Main Methods:

  • MSCs were cultured in PLA and PLA/alginate scaffolds with or without TGF-beta1.
  • Chondrogenesis was assessed using histology, immunohistochemistry, SEM, sulfate incorporation, and RT-PCR.

Main Results:

  • TGF-beta1 treatment induced chondrogenic differentiation of MSCs within the PLA/alginate macrostructure.

Related Experiment Videos

  • Histological, molecular, and biochemical analyses confirmed chondrogenesis.
  • The PLA/alginate amalgam provided mechanical support and confined cells and growth factors.

    • Conclusions:

    • A stable 3D PLA/alginate amalgam system supports mesenchymal chondrogenesis.
    • This system is a promising candidate for investigating factors influencing cartilage development.
    • It holds potential as a tissue engineering construct for cartilage repair.