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Related Experiment Videos

Tissue engineering: functional assessment and clinical outcome.

Steven A Goldstein1

  • 1Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, University of Michigan, 400 North Ingalls, Ann Arbor, MI 48109-0486, USA. stevegld@umich.edu

Annals of the New York Academy of Sciences
|June 26, 2002
PubMed
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This review outlines a framework for developing tissue engineering constructs for clinical use. It focuses on critical parameters for translating lab discoveries into patient treatments.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Clinical Translation

Background:

  • Tissue engineering aims to restore, maintain, or improve tissue function.
  • Translating tissue-engineered constructs from laboratory research to clinical application presents significant challenges.
  • A structured approach is needed to guide the development and evaluation process.

Purpose of the Study:

  • To provide a general framework for the design and evaluation of tissue engineering constructs.
  • To identify critical parameters for the clinical application of tissue-engineered products.
  • To outline a sequence of activities for moving tissue engineering from concept to clinical reality.

Main Methods:

  • Review of key considerations in tissue engineering construct development.

Related Experiment Videos

  • Identification of critical parameters for clinical translation.
  • Organization of information into a feasible sequence of activities.
  • Use of examples from current laboratory studies.

    • Main Results:

    • A comprehensive framework for tissue engineering development is presented.
    • Critical parameters for successful clinical application are highlighted.
    • The focus is on the process and parameters, not specific engineering solutions.

    Conclusions:

    • A systematic approach is essential for the successful clinical translation of tissue engineering.
    • Careful consideration of design and evaluation parameters is crucial.
    • This framework facilitates the progression of tissue engineering from the laboratory to the patient.