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Related Experiment Videos

[Weight gain after functional surgery for Parkinsons disease].

A Gironell1, B Pascual-Sedano, P Otermin

  • 1Secció De Trastorns del Moviment, Servei de Neurologia, Hospital de Sant Pau, Universitat Autònoma de Barcelona, Spain. agironell@correu.vilaweb.com

Neurologia (Barcelona, Spain)
|June 27, 2002
PubMed
Summary

Functional surgery for Parkinson's disease (PD) leads to weight gain in most patients, often linked to improved motor function and reduced dyskinesias. This weight gain is generally benign and may stem from decreased energy expenditure post-surgery.

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Area of Science:

  • Neuroscience
  • Neurosurgery
  • Metabolic Research

Context:

  • Parkinson's disease (PD) management involves surgical interventions like pallidal or subthalamic nucleus surgery.
  • Weight gain is a frequently observed but poorly understood outcome following these functional neurosurgeries.

Purpose:

  • To investigate the causes and characteristics of weight gain after pallidal and subthalamic surgery in Parkinson's disease patients.
  • To analyze the correlation between weight gain and post-operative changes in motor function, medication, and patient-reported symptoms.

Summary:

  • A prospective study of 27 PD patients undergoing pallidal or subthalamic surgery revealed significant weight gain (mean 4.7 kg at 12 months) in 26 patients.
  • Weight gain correlated positively with improvements in dyskinesias (AIMS) and motor scores (UPDRS Part III), and negatively with pre-operative weight.

Related Experiment Videos

  • Bilateral pallidal surgery resulted in more pronounced weight gain compared to unilateral procedures; most patients considered it a minor adverse event secondary to symptom improvement.

    • Impact:

    • Functional surgery for PD, irrespective of the target, consistently induces weight gain.
    • This weight gain is typically benign and likely attributable to a reduction in energy expenditure post-surgery.
    • Findings suggest a need to monitor and potentially manage weight changes as part of post-operative care for PD patients.