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Updated: Aug 8, 2026

Particle Agglutination Method for Poliovirus Identification
Published on: April 20, 2011
Lack of association between intussusception and oral polio vaccine in Cuban children
M A Sardiñas1, A Z Cárdenas, G C Marie
1Direccion Nacional de Epidemiologia, MINSAP, Ciudad de la Habana, Cuba.
Abstract:
Two exploratory investigations found an increased risk of intussusception after oral polio vaccine (OPV). A large, national, population-based study was undertaken in Cuba to investigate a possible association. Three hundred and thirty-five cases of intussusception in children under 2 years of age occurring in 1995-2000 were identified and their OPV records retrieved. The relative incidence (RI) of intussusception in defined periods up to 42 days after OPV in children under 1 year was estimated using the self-controlled case series method, controlling for age and season. The RI was not significantly raised in any of the time intervals examined within the 0-42 day period after OPV. For the period 0-42 days as a whole the RI was 1.11, 95% CI 0.74-1.67. This study does not support the hypothesis that OPV causes intussusception.
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