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08:01
Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices
Published on: August 14, 2015
Spatiotemporal expression of NGFR during pre-natal human tooth development
K B Becktor1, B F Hansen, D Nolting
1Department of Orthodontics, School of Dentistry, University of Copenhagen, Denmark.
Orthodontics & Craniofacial Research
|June 28, 2002
Summary
Nerve growth factor receptor (NGFR) shows a distinct pattern in developing human tooth buds. Its expression changes in the enamel epithelium and dental follicle as tooth development progresses.
Area of Science:
- Developmental biology
- Oral biology
- Histology
Background:
- The nerve growth factor receptor (NGFR), specifically p75NGFR, plays a role in neural development.
- Understanding NGFR expression in early tooth development is crucial for insights into odontogenesis.
Purpose of the Study:
- To investigate the relationship between NGFR and the dental follicle in human prenatal tooth buds.
- To identify specific patterns of p75NGFR expression during human tooth development.
Main Methods:
- Histological sections from 11 human fetuses (11-21 gestational weeks) were analyzed.
- Conventional immunohistochemistry was employed to detect p75NGFR.
Main Results:
- p75NGFR immunoreactivity was observed throughout the inner enamel epithelium and dental follicle before matrix production.
- Immunoreactivity decreased in matrix-producing cells and adjacent dental follicle tissue after matrix production began.
Conclusions:
- A unique spatiotemporal distribution of NGFR was identified in the pre-eruptive human tooth bud.
- These findings highlight the dynamic role of NGFR during early tooth morphogenesis.
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