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Updated: Sep 4, 2026
Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat
Published on: October 29, 2014
Diarrhea in Neonatal Rats
Naomi M. Gades1, Timothy D. Mandrell, William P. Rogers
1The University of Tennessee, Memphis, Department of Comparative Medicine, 956 Court Avenue, Box 17, Memphis, TN 38163.
Abstract:
A litter of eight 10- to 12-day-old SPF Sprague-Dawley rat pups (Rattus norvegicus) was observed as runted, with rough, yellow-discolored hair coats and perineal scalding and soiling. The dam also had soft stool and perineal soiling. Both the dam and pups were active despite their unthrifty appearance. The clinical signs were consistent with diarrhea. Differential diagnoses for diarrhea in neonatal rats were considered, including bacterial, viral, and parasitic etiologies. The dam and pups were sacrificed, and the following diagnostic tests were performed: complete blood count, serology, necropsy, bacterial culture, and histopathology. Histopathology and culture results were consistent with a diagnosis of streptococcal enteropathy.
