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Pamidronate-associated nephrotoxicity in a patient with Langerhans's histiocytosis
Les Lockridge1, Rose J Papac, Mark A Perazella
1Department of Medicine, Section of Oncology and Section of Nephrology, Yale University, New Haven, CT 06529-8029, USA.
Abstract:
Pamidronate is used frequently to treat malignancy-associated hypercalcemia and osteolytic lesions. This widely used bisphosphonate has been noted to cause nephrotoxicity in patients with multiple myeloma and metastatic breast cancer. We encountered a patient with Langerhans's histiocytosis who developed nephrotic syndrome and renal failure after pamidronate therapy. We describe the clinical and renal biopsy findings in this patient.