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Local antiseptic therapy for non-gonococcal urethritis: phase II study with Instillagel
H Sperling1, H P Bastian, F Boeminghau
1Urologische Klinik der Universität Essen, Germany. herbert.sperling@uni-essen.de
World Journal of Urology
|June 29, 2002
Summary
Local antiseptic Instillagel effectively treated non-gonococcal urethritis (NGU) symptoms in a Phase II study. This localized approach offers a promising alternative to oral antibiotics for NGU patients.
Area of Science:
- Urology
- Infectious Diseases
- Pharmacology
Background:
- Non-gonococcal urethritis (NGU) is a common condition typically managed with oral antibiotics.
- The need for alternative treatments with potentially fewer systemic side effects is recognized.
Purpose of the Study:
- To investigate the efficacy of a locally disinfecting substance, Instillagel, as a treatment for symptomatic NGU.
- To evaluate Instillagel's impact on urethral microbial counts and patient-reported symptoms.
Main Methods:
- A Phase II study involving 32 male patients with symptomatic NGU.
- Instillagel was administered twice daily via urethral instillation.
- Urethral smears, urine examinations, and symptom questionnaires (pain, micturition) were used for evaluation at baseline and follow-up.
Main Results:
- Significant reduction in urethral microbial presence (P < 0.0001).
- Marked improvement in micturition symptoms (P < 0.0001) and urethral pain (P < 0.0001).
- No significant changes were observed in urine microbial counts.
Conclusions:
- Local antiseptic treatment with Instillagel is a viable alternative to systemic antibiotics for NGU.
- This localized therapy demonstrates significant clinical benefits in reducing NGU symptoms.