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Temozolomide-induced flare in high-grade gliomas: a new clinical entity
M A Rosenthal1, D L Ashley, L Cher
1Department of Medical Oncology and Clinical Haematology, Royal Melbourne Hospital, Parkville, Victoria, Australia. mark.rosenthal@mh.org.au
Internal Medicine Journal
|June 29, 2002
Abstract:
A transient deterioration in neurological status following commencement of chemotherapy for high-grade gliomas has not been previously described. We report eight cases of transient deterioration following administration of temozolomide, a relatively new cytotoxic agent used in the treatment of high-grade gliomas. We believe this represents the novel clinical entity of temozolomide-induced tumour flare.