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NK cell receptors in antiviral immunity
Janice M Moser1, Anthony M Byers, Aron E Lukacher
1Department of Pathology, Woodruff Memorial Research Building, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA.
Current Opinion in Immunology
|June 29, 2002
Abstract:
An array of inhibitory and activating receptors initially identified on NK cells are also expressed by conventional CD8+ alphabeta T cells. New evidence strongly implicates these 'NK cell receptors' in modulating NK cell and virus-specific CD8+ T cell responses against a variety of viral infections. Precise regulation of NK cell and T cell responses by these receptors optimizes antiviral immunity while preventing immunological bystander pathology and autoimmunity.