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Does dobutamine improve ventricular function in dogs with regional myocardial dysfunction?

David P Strum1, Michael R Pinsky

  • 1Department of Anesthesiology and Critical Care Medicine, Kingston General Hospital, Queen's University, 76 Stuart Street, Kingston, Ontario K7L 2V7, Canada. strumd@post.queensu.ca

Anesthesia and Analgesia
|June 29, 2002
PubMed
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Systemic dobutamine improved overall heart function but did not resolve regional wall motion abnormalities (RWMAs) caused by esmolol. Dobutamine restored global ventricular function, yet RWMA persisted, impacting regional synchrony.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Regional wall motion abnormalities (RWMAs) impair cardiac function.
  • Dobutamine is a common inotropic agent used to improve cardiac output.

Purpose of the Study:

  • To investigate the effect of systemic dobutamine on esmolol-induced RWMAs.
  • To assess dobutamine's impact on global and regional left ventricular (LV) function.

Main Methods:

  • RWMAs were induced in anesthetized dogs using intracoronary esmolol.
  • Systemic dobutamine was administered to assess its effects on cardiac function.
  • Regional phase angles, stroke volume (SV), and stroke work were measured in different LV regions.

Main Results:

  • Esmolol-induced RWMAs decreased blood pressure and delayed regional contraction.

Related Experiment Videos

  • Systemic dobutamine improved global LV function but did not eliminate RWMAs.
  • Dobutamine failed to restore synchrony in the affected apical region, with decreased effective SV and stroke work.

    • Conclusions:

    • Systemic dobutamine effectively restores global LV function in the presence of RWMAs.
    • Dobutamine does not fully correct esmolol-induced RWMAs, indicating persistent regional dysfunction.
    • Further strategies may be needed to address regional asynchrony in cardiac dysfunction.