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Orthotopic Aortic Transplantation in Mice for the Study of Vascular Disease
Published on: November 28, 2012
Fatal Saccharomyces cerevisiae aortic graft infection
Davey Smith1, David Metzgar, Christopher Wills
1Departments of Medicine, University of California at San Diego, La Jolla, California 92093, USA. d13smith@ucsd.edu
Abstract:
Saccharomyces cerevisiae is a yeast commonly used in baking and a frequent colonizer of human mucosal surfaces. It is considered relatively nonpathogenic in immunocompetent adults (J. N. Aucott, J. Fayan, H. Grossnicklas, A. Morrissey, M. M. Lederman, and R. A. Salata, Rev. Infect. Dis. 12:406-411, 1990). We present a case of S. cerevisiae fungemia and aortic graft infection in an immunocompetent adult. This is the first reported case of S. cerevisiae fungemia where the identity of the pathogen was confirmed by rRNA sequencing.
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