Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Childhood toxoplasmosis today].

S Goţia1, A Murgu, C Ailioaic

  • 1Facultatea de Medicină Clinica a II a Pediatrie, Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi
|July 2, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Up-date in the renin-angiotensin system. 1) Peculiarities in children].

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2014
Same author

Asthma: specific clinical and functional characteristics in childhood. Results of a national program in Romanian asthmatic children.

European annals of allergy and clinical immunology·2011
Same author

[Psychogenic pain in children].

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2009
Same author

[Arterial stiffness in pediatric hypertension].

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2007
Same author

[Remission of primary vesicoureteral reflux in children with medical management].

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2006
Same author

[Treatment outcome using prednisone in corticosteroid-responsive primary nephrotic syndrome in children].

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2006

This study highlights the rise in congenital toxoplasmosis and the prevalence of subclinical acquired toxoplasmosis. Individualized treatment is crucial, with Rovamicine showing comparable efficacy to Pirimetamine-Trimetoprim.

Area of Science:

  • Medical Parasitology
  • Pediatric Infectious Diseases
  • Public Health

Background:

  • Toxoplasmosis, caused by *Toxoplasma gondii*, presents challenges in diagnosis and treatment, particularly in congenital and acquired forms.
  • The study examines trends in toxoplasmosis over two decades, noting changes in disease manifestation and co-morbidities.
  • Increasing rates of immunodeficiency-generating diseases necessitate a re-evaluation of *Toxoplasma gondii* screening protocols.

Purpose of the Study:

  • To compare acquired and congenital toxoplasmosis in children across two distinct time periods.
  • To assess the efficacy of different treatment regimens for toxoplasmosis.
  • To emphasize the need for systematic *Toxoplasma gondii* screening and individualized therapeutic approaches.

Main Methods:

Related Experiment Videos

  • A comparative analysis of two pediatric patient cohorts hospitalized for toxoplasmosis between 1979-1985 (n=39) and 1991-1997 (n=117).
  • Evaluation of clinical manifestations, focusing on atypical and subclinical presentations of acquired toxoplasmosis.
  • Assessment of treatment outcomes comparing Rovamicine with Pirimetamine-Trimetoprim, considering co-existing conditions.

Main Results:

  • A significant proportion (54%) of acquired toxoplasmosis cases exhibited atypical or subclinical symptoms, underscoring the need for proactive screening.
  • Congenital toxoplasmosis incidence increased from 5% to 8% between the two study periods, highlighting potential gaps in maternal screening.
  • Rovamicine demonstrated comparable therapeutic effectiveness to Pirimetamine-Trimetoprim, suggesting treatment options despite limited therapeutic choices and drug resistance.
  • Co-morbidities such as chronic hepatitis B, tuberculosis, and HIV infection were prevalent, complicating treatment decisions.

Conclusions:

  • Systematic *Toxoplasma gondii* screening is essential, especially in at-risk populations and pregnant women, due to the rising incidence of congenital toxoplasmosis and subclinical acquired infections.
  • Treatment for toxoplasmosis requires a personalized approach, considering the patient's overall health status and the presence of other diseases.
  • Rovamicine offers a viable alternative treatment option, with efficacy similar to established regimens like Pirimetamine-Trimetoprim.