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Modulation of myocardial function by pyruvate.

A F Leite-Moreira1, M S Guerra, P Castro-Chaves

  • 1Serviço de Fisiologia, Faculdade de Medicina, Universidade do Porto, Porto, Portugal. amoreira@med.up.pt

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|July 2, 2002
PubMed
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Pyruvate enhances heart muscle contraction in a dose-dependent manner, acting independently of mitochondrial uptake. This suggests pyruvate is beneficial for metabolic heart protection, especially during ischemia.

Area of Science:

  • Cardiology
  • Metabolic Biochemistry

Background:

  • Pyruvate, a glycolytic intermediate, exhibits a positive inotropic effect in cardiac models.
  • Understanding the mechanisms of pyruvate's inotropic effect is crucial for cardiac function research.

Purpose of the Study:

  • To elucidate the mechanisms behind pyruvate's positive inotropic effect on cardiac muscle.
  • To investigate the role of mitochondrial pyruvate uptake in this effect.

Main Methods:

  • Experiments were conducted on isolated rabbit papillary muscles and human atrial trabeculae.
  • Pyruvate was administered at varying concentrations (3, 10, 15 mM) with or without mitochondrial inhibitors.
  • Key contractile parameters including active tension and velocity of shortening were measured.

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Main Results:

  • Pyruvate induced a dose-dependent positive inotropic effect, significantly increasing myocardial contractility.
  • A transient negative inotropic effect was observed at lower pyruvate concentrations in rabbit models.
  • The positive inotropic effect in rabbit papillary muscles was independent of mitochondrial pyruvate uptake.

Conclusions:

  • Pyruvate enhances cardiac contractility in both rabbit and human heart tissues.
  • The beneficial effects of pyruvate on cardiac contractility do not rely on mitochondrial pyruvate metabolism.
  • Pyruvate shows promise for metabolic heart protection, particularly in conditions like myocardial ischemia.