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Comparative study of marginal zone lymphoma involving bone marrow
Sara A Kent1, Daina Variakojis, LoAnn C Peterson
1Department of Pathology, Northwestern University Medical School, Chicago, IL, USA.
American Journal of Clinical Pathology
|July 2, 2002
Summary
Bone marrow involvement is common in marginal zone lymphomas, particularly splenic marginal zone lymphoma (SMZL). Extranodal marginal zone lymphoma (EMZL) also frequently involves the bone marrow, with varying infiltration patterns observed across subtypes.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Marginal zone lymphomas (MZLs) encompass extranodal (EMZL), splenic (SMZL), and nodal (NMZL) subtypes.
- Limited comparative data exists on bone marrow (BM) pathology across these MZL subtypes.
Purpose of the Study:
- To characterize and compare the pathologic features of bone marrow involvement in EMZL, SMZL, and NMZL.
Main Methods:
- Analysis of 45 bone marrow biopsy specimens from 39 patients diagnosed with MZLs.
- Evaluation of infiltration patterns and extent in relation to MZL subtype.
Main Results:
- Bone marrow involvement was universal in SMZL (100%) and frequent in EMZL (44%).
- Infiltration patterns were mixed across subtypes, with greater extent in SMZL compared to EMZL.
- Intrasinusoidal infiltration was common in SMZL (83%) but also observed in EMZL (55%) and other small B-cell disorders.
Conclusions:
- Bone marrow involvement is a significant feature across MZL subtypes, with distinct prevalence and patterns.
- Intrasinusoidal infiltration in bone marrow is characteristic of SMZL but not exclusive to it.