Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Proteopathy: the next therapeutic frontier?

Lary C Walker1, Harry LeVine

  • 1CNS Pharmacology, Pfizer Ann Arbor Laboratories, MI 48105, USA. lary.walker@pfizer.com

Current Opinion in Investigational Drugs (London, England : 2000)
|July 2, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Subconjunctival Triamcinolone Acetonide Injection Compared with Dexamethasone Ophthalmic Insert for Inflammation Prophylaxis After Cataract Surgery: A Comparative Clinical Study.

Clinical ophthalmology (Auckland, N.Z.)·2026
Same author

Management of Post-Operative Inflammation After Cataract Surgery with Intracanalicular Dexamethasone Implant and Topical Ketorolac.

Clinical ophthalmology (Auckland, N.Z.)·2026
Same author

Perspectives on eye care access and telemedicine-based glaucoma screening among Latine individuals with limited English proficiency.

AJO international·2025
Same author

Hardware-efficient quantum error correction via concatenated bosonic qubits.

Nature·2025
Same author

The prion principle and Alzheimer's disease.

Science (New York, N.Y.)·2024
Same author

Dexamethasone Intracanalicular Insert versus Standard Topical Steroids for the Prophylaxis of Inflammation after Cataract Surgery.

American journal of ophthalmology·2024

Protein misfolding causes age-related diseases like Alzheimer's and Parkinson's. Understanding these proteopathies may lead to new treatments targeting protein production, assembly, or removal.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Pathology

Background:

  • Abnormal protein conformation and self-assembly are implicated in numerous age-related degenerative diseases, collectively known as proteopathies.
  • These diseases encompass a range of neurological disorders, including Alzheimer's disease, Parkinson's disease, and Creutzfeldt-Jakob disease, as well as non-neurological conditions.
  • While the role of protein pathology is recognized, the fundamental origins of proteopathies remain largely unknown.

Purpose of the Study:

  • To explore the underlying causes and therapeutic strategies for proteopathies.
  • To consolidate current understanding of protein self-assembly in disease pathogenesis.
  • To identify key targets for therapeutic intervention in protein misfolding diseases.

Main Methods:

Related Experiment Videos

  • Review of existing literature on protein conformation, self-assembly, and disease mechanisms.
  • Analysis of established and emerging therapeutic approaches targeting protein pathology.
  • Synthesis of current knowledge regarding the origins and progression of proteopathies.

    • Main Results:

    • Protein misfolding and aggregation are central to the pathogenesis of diverse degenerative diseases.
    • Understanding the mechanisms of protein self-assembly and tissue injury is advancing.
    • Three primary therapeutic avenues are proposed: reducing protein production, inhibiting self-assembly, or enhancing protein clearance.

    Conclusions:

    • Proteopathies represent a significant class of age-related diseases driven by protein misfolding.
    • Further research into the origins of proteopathies is crucial for developing effective treatments.
    • Targeting protein production, assembly, or removal offers promising therapeutic strategies for managing these debilitating conditions.