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Updated: Aug 18, 2026

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
Published on: September 9, 2016
Original method for nicorandil synthesis
1School of Medical Bioengineering, Gr.T. Popa University of Medicine and Pharmacy, Iaşi.
Abstract:
Nicorandil (N-(2-hydroxy-ethyl)-nicotine amide nitrate), drug recently introduced in therapy, is used as a vasodilator through potassium channel activation. Nicorandil is obtained by treating nicotinic acid chloride hydrochloride with nitro-oxy-ethyl-amine nitrate in an organic solvent. The authors suggest a method that uses ethyl nicotinate as raw material. Thus, the drug can be obtained from indigenous raw materials, at a lower price than the imported ones, with a high purity and a good yield.
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