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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
[Investigations for obtaining compounds with potential antiinflammatory action, carboxymethylic ethers of some
M Ungureanu1, G Alexandrescu, Z Cojocaru
1Institutul de medicină şi farmacie Iaşi.
Abstract:
In this paper the synthesis of 5 etheric derivates of some aromatic oxymes: p-metoxy-benz-(sin)-aldoxyme, p-chlorine-benz-(sin)-aldoxyme, sin-piperonal-oxyme, 2,4-di- chlorinebenzaldoxyme and 3,4-dichlor-benzaldoxyme were described. In view of a subsequent study on the antiinflammatory action a simple method for obtaining these compounds based on the reaction between the sodium salt of the monochloracetic acid and the sodium derivates of the corresponding oxymes. The structure of the newly obtained products was confirmed by the elementary quantitative chemical analysis and the spectral analysis in IR.
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