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[Thyroxine therapy in benign thyroid nodules].

C Vulpoi1, E Zbranca, V Mogoş

  • 1Clinica de Endocrinologie, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi
|July 3, 2002
PubMed
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Levothyroxine (LT4) treatment for benign thyroid nodules showed a modest benefit compared to no treatment. Smaller nodules responded better, but potential side effects suggest selective use.

Area of Science:

  • Endocrinology
  • Thyroidology
  • Nuclear Medicine

Background:

  • Levothyroxine (LT4) treatment for benign thyroid nodules is controversial, with variable reported response rates.
  • Studies show comparable outcomes between treated and untreated groups in some cases.

Purpose of the Study:

  • To evaluate the response of benign, uninodular goiters to Levothyroxine (LT4) treatment compared to an untreated control group.
  • To assess factors influencing treatment response, such as initial nodule volume and iodine supply.

Main Methods:

  • A study group (S) of 53 patients with benign thyroid nodules received LT4 for 1 year.
  • A control group (C) of 26 age- and sex-matched patients with similar nodules remained untreated.
  • All patients were from an area with minor iodine deficiency and met criteria for euthyroidism, single solid cold benign nodules.

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Main Results:

  • Both groups showed a significant decrease in mean nodular volume after 1 year.
  • The LT4-treated group (S) had a higher volume reduction (35%) than the untreated group (C) (25%).
  • Nodules smaller than 5 mL showed a significantly higher response rate (51.5%) to LT4 compared to larger nodules (>5 mL) (19.6%).

Conclusions:

  • Levothyroxine (LT4) treatment demonstrated a slightly significant benefit in reducing benign thyroid nodule volume compared to no treatment.
  • The response to LT4 may be influenced by iodine supply, with better outcomes observed in iodine-deficient areas.
  • Given potential LT4 side effects, this treatment should be reserved for selected cases of benign thyroid nodules.