Related Experiment Videos
[Lymphocyte traffic in the events that follow lymphocytes activation in the germinal centre]
1Facultatea de Medicină Stomatologică, Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi.
After their maturation, lymphocytes migrate from the primary lymphoid organs to the secondary lymphoid organs and tissues. Once in the secondary tissues the lymphocytes do not simply remain there; many move from one lymphoid organ to another via the blood and lymph. This process allows a large number of antigen-specific lymphocytes to come in contact with their appropriate antigen in the microenvironment of the peripheral lymphoid organs and this is important since lymphocytes are monospecific and only a limited number of cells are able to recognize and interact with a particular antigen. When B cells are activated by antigen, with the help from the T cells, they mature either into AFCs (Antibody-Forming Cells), or they develop into memory cells. The germinal centers in various lymphoid tissues represent the sites of the immune response development and memory B cells generation. At these sites, the B cells undergo active hypermutation of the variable genes, a process that can lead to death by apoptosis for some cells.
After their maturation, lymphocytes migrate from the primary lymphoid organs to the secondary lymphoid organs and tissues. Once in the secondary tissues the lymphocytes do not simply remain there; many move from one lymphoid organ to another via the blood and lymph. This process allows a large number of antigen-specific lymphocytes to come in contact with their appropriate antigen in the microenvironment of the peripheral lymphoid organs and this is important since lymphocytes are monospecific and only a limited number of cells are able to recognize and interact with a particular antigen. When B cells are activated by antigen, with the help from the T cells, they mature either into AFCs (Antibody-Forming Cells), or they develop into memory cells. The germinal centers in various lymphoid tissues represent the sites of the immune response development and memory B cells generation. At these sites, the B cells undergo active hypermutation of the variable genes, a process that can lead to death by apoptosis for some cells.