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Release of hemorphin-5 from human hemoglobin by pancreatic elastase
Yunden Jinsmaa1, Masaaki Yoshikawa
1Graduate School of Agriculture, Kyoto University, Uji, Japan.
Bioscience, Biotechnology, and Biochemistry
|July 3, 2002
Abstract:
Opioid peptide hemorphin-5 (YPWTQ) was released from human hemoglobin by the action of pancreatic elastase. V-hemorphin-5 (VYPWTQ) was also released under the same conditions. The amount of hemorphin-5 was about 1/10 that of V-hemorphin-5. This is the first report showing release of hemorphin-5 only by the action of one enzyme.