Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Food-drug interactions.

Lars E Schmidt1, Kim Dalhoff

  • 1Department of Clinical Pharmacology Q.7642, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.

Drugs
|July 3, 2002
PubMed
Summary
This summary is machine-generated.

Food and drug interactions significantly impact drug effectiveness by altering bioavailability. Understanding these food-drug interactions is crucial for preventing treatment failure and adverse effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Central nervous system penetration of imatinib in acute lymphoblastic leukemia: Pharmacokinetic analysis and clinical implications.

Cancer chemotherapy and pharmacology·2026
Same author

Hepatic CYP1A2 Activity in Adolescents with and without Obesity Assessed by the Urinary Paraxanthine-to-Caffeine Metabolic Ratio: A Pharmacokinetic Study.

Journal of clinical pharmacology·2026
Same author

Pharmacokinetic profiling of imatinib in relation to CYP3A4 activity in leukaemia patients.

British journal of clinical pharmacology·2026
Same author

Ugeskrift for laeger·2026
Same author

A prospective pharmacokinetic study of chlordiazepoxide in patients admitted to an intensive care unit or a high dependency unit after treatment of alcohol withdrawal symptoms.

Clinical toxicology (Philadelphia, Pa.)·2026
Same author

The Effect of ABCB1 Polymorphisms on the Efficacy of Antidepressants.

Basic & clinical pharmacology & toxicology·2025
Same journal

Botulinum Toxin Type A for Trigeminal and Postherpetic Neuralgia: An Umbrella Review of Systematic Reviews.

Drugs·2026
Same journal

Biologics and Small Molecule Inhibitors: Novel Therapeutic Strategies for Cutaneous Adverse Drug Reactions.

Drugs·2026
Same journal

Use of Sedative-Hypnotic Drugs and the Risk of Developing Alzheimer's Disease: A Systematic Review, Meta-Analysis and Meta-Regression.

Drugs·2026
Same journal

Relacorilant: First Approval.

Drugs·2026
Same journal

Developmental Progress and Future Potential for Inhaled Biologics in the Treatment of Respiratory Diseases.

Drugs·2026
Same journal

Linerixibat: First Approval.

Drugs·2026
See all related articles

Area of Science:

  • Pharmacology
  • Drug Interactions
  • Clinical Pharmacy

Background:

  • Food and drug interactions can alter drug efficacy and safety.
  • Most clinically relevant interactions involve changes in drug bioavailability.
  • Identifying and preventing adverse food-drug interactions is a growing healthcare priority.

Purpose of the Study:

  • To review pharmacokinetic and clinical effect parameters of clinically relevant food-drug interactions.
  • To highlight interactions with a high risk of treatment failure due to reduced bioavailability.
  • To categorize mechanisms of food-drug interactions.

Main Methods:

  • Review of original literature.
  • Analysis of pharmacokinetic parameters (bioavailability).

Related Experiment Videos

  • Evaluation of clinical effect parameters.

    • Main Results:

    • Interactions often reduce bioavailability via chelation (e.g., tetracyclines) or dairy products (e.g., fluoroquinolones).
    • Physiological responses to food (gastric acid, bile) can decrease or increase bioavailability.
    • Increased bioavailability can enhance therapeutic effects or cause toxicity (e.g., halofantrine).

    Conclusions:

    • Food-drug interactions significantly affect drug bioavailability and clinical outcomes.
    • Chelation, dairy, and physiological responses are key interaction mechanisms.
    • Quantifying these interactions is essential for safe and effective drug therapy.