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Smallpox: anything to declare?

Geoffrey L Smith1, Grant McFadden

  • 1Department of Virology, The Wright Fleming Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, St Mary's Campus, Norfolk Place, London W2 1P6, UK. glsmith@ic.ac.uk

Nature Reviews. Immunology
|July 3, 2002
PubMed
Summary
This summary is machine-generated.

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Smallpox eradication was a major public health success. However, the variola virus poses a bioterrorism threat, necessitating preparedness for potential re-emergence and engineered orthopoxviruses.

Area of Science:

  • Public Health
  • Infectious Diseases
  • Virology

Background:

  • Smallpox, a devastating infectious disease, was globally eradicated in 1977 through a concerted vaccination effort led by the World Health Organization.
  • The variola virus, responsible for smallpox, is now a significant concern due to its potential misuse as a bioterrorism agent.

Observation:

  • Despite eradication, the variola virus is maintained in secure laboratory facilities worldwide.
  • Natural and genetically engineered orthopoxviruses present additional public health risks.

Findings:

  • The article reviews the historical success of smallpox eradication and assesses current global preparedness strategies.
  • It highlights the potential for variola virus re-emergence through accidental release or deliberate bioterrorism.

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Implications:

  • Maintaining vigilance and robust biosecurity measures are crucial to prevent smallpox re-emergence.
  • Preparedness for bioterrorism threats involving variola virus and other orthopoxviruses is essential for global health security.