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Circulating IL-6 and sIL-6R in patients with hepatocellular carcinoma
L Giannitrapani1, M Cervello, M Soresi
1Istituto di Medicina Interna e Geriatria, Università di Palermo, Palermo, Italy.
Annals of the New York Academy of Sciences
|July 4, 2002
Abstract:
Interleukin-6 plays a central role in regulating the immune system, hematopoiesis, and acute phase reaction. It interacts with a receptor complex consisting of a specific ligand-binding protein (IL-6R, gp80) and a signal transduction protein (gp130). In this report, serum levels of IL-6 and a soluble form of the interleukin-6 receptor (sIL-6R) were evaluated in patients with hepatocellular carcinoma. The correlation between IL-6 and sIL-6R values, the stage of hepatocellular carcinoma, and main liver function tests was also studied.