[Effect of yeast mannans on aldolase of rat blood serum]

The activity of aldolase in rat blood serum was studied in experiments in vitro and in vivo as affected by extracellular mannan of Rhodotorula rubra. It was established that in vitro the polysaccharide has an inhibitory effect in the enzyme and in vivo, vice versa, activates it. The maximal activation is observed against a background of the V increase and Km decrease. By the preparative electrophoresis in 7.5% polyakrylamide gel seven isoenzymes of aldolase are obtained. After introduction of the polysaccharide the activity in the individual isoforms of the enzyme increases.