[The effect of surface-active drug on properties of trypsin monolayers]

When the monolayers of trypsin are compressed on the surface of the medicinal substances solution they remain mixed even when high pressure is applied. The experiments on reversibility also indicate that certain medicinal substances remain in the monolayers. An increase in the surface pressure causes partial (dimedrol, barbamyl) or complete (analgin, amidopyrin) displacement of medicinal substances out of the trypsin monolayer. This proves that there is no strong interaction between them. Unlike proteins, the monolayer of acetyl alcohol is less penetrable and indicates the absence of interaction with dimedrol where the mature of the monolayer is of great importance.