[Content of glycoproteins in rat blood in experimental hypothyreosis]

The data are presented of parallel studies of the effect of different "thyreostatic" remedies as applied to concentration of certain glycoproteid components of blood in rats. Dynamics and correlation of disturbances were studied between the changes in the content of the glycidogram fractions and blood carbohydrate-containing glycoproteids. An essential change in glycoproteid blood metablolism is established. It is characterized by a significant decrease in the concentration of albumin alpha2- and gamma-globulin factors of the glycidogram and creuloplasmin as well as by a simultaneous rise in the level of alpha1- and beta-globulin fractions, hexosamine, haptoglobin, transferrine and L-fucose in the animals under experiment. The value of changes in the blood serum glycoproteid tests under study is determined as dependent on the type of the "thyreostatic" remedy, dose and duration time of the thyreostatic preparation administration. The maximal tine was established for an increase in the content of certain glycoproteids during the experiment and in different periods after it. An attempt is also made to explain the reasons affecting the disturbances of glycoproteid metabolism in blood with hypothyreosis in rats.