Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A vasorelaxing factor is released from mouse retinal tissue.

Koen Boussery1, Ann Sophie Franki, Christophe Delaey

  • 1Department of Physiology and Pathophysiology, Ghent University, De Pintelaan 185, Blok B, B-9000 Ghent, Belgium.

Ophthalmic Research
|July 5, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

External Validation of a Community Pharmacy-Based Screening Tool for Frailty That Uses Routinely Collected Data.

Drugs & aging·2026
Same author

Understanding quality of life in chronic non-cancer pain: untangling the associations between medication use, psychosocial functioning, and stigma.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2026
Same author

Meta-Analysis on the Harm of Systemic Glucocorticosteroids in Inflammatory Upper Airway Disease and Asthma: An EAACI Task Force.

Allergy·2026
Same author

A survey of community pharmacists perspectives on monitoring antidepressant adverse events.

British journal of clinical pharmacology·2026
Same author

Perspectives of primary care healthcare professionals on interventions aimed at reducing the environmental impact of medicines: a mixed-methods systematic review protocol.

HRB open research·2026
Same author

Community Pharmacists' Role in Antidepressant Discontinuation: A Survey of Barriers and Facilitators.

Basic & clinical pharmacology & toxicology·2026
Same journal

The Link Between Obstructive Sleep Apnea and Dry Eye Disease: Pathophysiology and Current Updates.

Ophthalmic research·2026
Same journal

Retraction Statement.

Ophthalmic research·2026
Same journal

Correlations between Clinical Activity Score and Serological and Radiological Data in Treatment-naïve Ethnic Han Chinese Thyroid Eye Disease.

Ophthalmic research·2026
Same journal

Stem Cell Based Interventions for Retinal Ganglion Cell Protection and Regeneration in Glaucoma: A Review of Current Evidence and Future Directions.

Ophthalmic research·2026
Same journal

Eye-Tracking Reading Patterns as Correlates of Clinical Measures in Glaucoma.

Ophthalmic research·2026
Same journal

A Matching-Adjusted Comparison of Faricimab and Aflibercept 8 mg in Neovascular Age-Related Macular Degeneration and Diabetic Macular Edema.

Ophthalmic research·2026
See all related articles

Mouse retinal tissue releases a novel relaxing factor (RRF). This factor

Area of Science:

  • Ophthalmology
  • Physiology
  • Vascular Biology

Background:

  • The retina's role in regulating ocular blood flow is crucial.
  • Understanding retinal vasoactive factors is key to managing visual health.

Purpose of the Study:

  • To confirm the existence of a retinal relaxing factor (RRF) in mice.
  • To identify the biochemical pathways involved in RRF-mediated vasodilation.

Main Methods:

  • Utilized a mouse aortic ring assay in a myograph.
  • Assessed relaxation responses to mouse retinal tissue.
  • Tested the effects of nitric oxide synthase and cyclooxygenase inhibitors.

Main Results:

  • Mouse retinal tissue induced significant aortic relaxation.

Related Experiment Videos

  • The RRF response was independent of nitric oxide (NO) and prostanoids.
  • Hypoxia markedly potentiated retina-induced relaxations.

    • Conclusions:

    • Mouse retina releases a non-NO, non-prostanoid relaxing factor.
    • Hypoxia significantly enhances the activity of this retinal relaxing factor.
    • This RRF may play a role in retinal vascular regulation.