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Related Experiment Videos

Conserved function for embryonic nodal cilia.

Jeffrey J Essner1, Kyle J Vogan, Molly K Wagner

  • 1Center for Children, Huntsman Cancer Institute and Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112-5550, USA.

Nature
|July 5, 2002
PubMed
Summary
This summary is machine-generated.

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Left-right handedness in vertebrates may stem from cilia-driven nodal flow. This study finds conserved monocilia and dynein gene expression across vertebrates, suggesting a common mechanism for establishing body plan asymmetry.

Area of Science:

  • Developmental Biology
  • Genetics
  • Evolutionary Biology

Background:

  • The origin of left-right handedness in vertebrate embryonic development is not fully understood.
  • In mice, nodal flow, generated by monocilia rotation in the embryonic node, is a proposed mechanism for establishing body asymmetry.

Purpose of the Study:

  • To investigate the conservation of monocilia and associated genes in vertebrate embryonic development.
  • To determine if a conserved ciliary mechanism underlies left-right handedness establishment across vertebrate classes.

Main Methods:

  • Examination of embryonic node structure across diverse vertebrate species.
  • Analysis of dynein gene expression, crucial for ciliary function, in developing embryos.

Main Results:

Related Experiment Videos

  • Node monocilia were found to be conserved across a wide range of vertebrate classes.
  • The expression of a key dynein gene implicated in ciliary function is also conserved.
  • These findings suggest a shared molecular basis for nodal flow generation.

Conclusions:

  • A conserved monocilia-based mechanism, involving dynein-dependent nodal flow, likely establishes left-right asymmetry in all vertebrates.
  • This study provides evidence for a common evolutionary origin of body plan handedness in vertebrates.