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Synthesis of 3,4-dihydro-2H-1,3,5-thiadiazines
Alan R Katritzky1, Anatoliy V Vakulenko, Yong-Jiang Xu
1Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA. katritzky@chem.ufl.edu
The Journal of Organic Chemistry
|July 6, 2002
Abstract:
3,4-Dihydro-2H-1,3,5-thiadiazines substituted at the 3 and 6 positions were synthesized by treatment of N-substituted N,N-bis(1H-1,2,3-benzotriazol-1-ylmethyl)-amines with thioamides and zinc bromide in dry CH(2)Cl(2) at room temperature for 48-60 h in 48-80% yields.