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Cough provocation tests: their clinical value.

R W Fuller1

  • 1The Wellcome Trust, 183, Euston Road, London, NW1 2BE, UK. r.fuller@wellcome.ac.uk

Pulmonary Pharmacology & Therapeutics
|July 9, 2002
PubMed
Summary
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Cough provocation testing is a valuable tool for developing new cough medicines and in epidemiological studies. While not ideal for routine clinical use, it is useful for assessing post-stroke patients and in hypothesis testing.

Area of Science:

  • Pharmacology
  • Respiratory Medicine
  • Clinical Trials

Background:

  • Cough provocation testing was initially developed to test new anti-tussive agents.
  • Methodologies include single breath and multiple breath techniques, with single breath techniques used in studies of over 100 patients.

Purpose of the Study:

  • To evaluate the utility of cough provocation testing in various clinical and research settings.
  • To assess the sensitivity of the cough reflex in patients with cough.

Main Methods:

  • Utilized single and multiple breath cough provocation techniques.
  • Conducted studies in patients with common cold and angiotensin converting enzyme inhibitor-associated cough.
  • Assessed cough reflex sensitivity in post-stroke patients.

Related Experiment Videos

Main Results:

  • Cough reflex is more sensitive in patients with cough and normalizes upon recovery.
  • Studies suggest a potential cause-and-effect relationship in common cold and ACE inhibitor-associated cough.
  • Cough provocation testing is superior to voluntary testing for assessing post-stroke cough reflex damage.

Conclusions:

  • Cough provocation testing is a valuable tool for epidemiological research and hypothesis testing.
  • Its utility is limited in routine clinical practice, with the exception of post-stroke patient assessment.
  • Further validation is needed for both single and multiple breath techniques.