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Floating microparticles based on low density foam powder.

A Streubel1, J Siepmann, R Bodmeier

  • 1College of Pharmacy, Freie Universität Berlin, Kelchstr. 31, 12169 Berlin, Germany.

International Journal of Pharmaceutics
|July 9, 2002
PubMed
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Researchers developed novel floating microparticles for gastroretentive drug delivery. These systems demonstrated high drug encapsulation and tunable release profiles, offering a promising approach for oral medications.

Area of Science:

  • Pharmaceutical Technology
  • Materials Science
  • Drug Delivery Systems

Background:

  • Gastroretentive drug delivery systems enhance drug absorption by prolonging gastric residence time.
  • Multiparticulate systems offer advantages in dose uniformity and flexibility compared to single-unit dosage forms.
  • Verapamil hydrochloride (HCl) is a model drug used to evaluate drug release from novel delivery systems.

Purpose of the Study:

  • To develop and characterize a novel multiparticulate gastroretentive drug delivery system using floating microparticles.
  • To investigate the influence of formulation and processing parameters on microparticle properties and drug release.
  • To evaluate the in vitro performance of the developed gastroretentive microparticles.

Main Methods:

  • Floating microparticles were prepared using an oil-in-water (O/W) solvent evaporation method.

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  • Materials included polypropylene foam powder, verapamil HCl (model drug), and polymers like Eudragit RS, ethylcellulose (EC), or polymethyl methacrylate (PMMA).
  • In vitro studies assessed particle morphology, drug loading, floating behavior, drug release kinetics, particle size, and drug's physical state.

    • Main Results:

    • Microparticles exhibited irregular shapes and high porosity with efficient drug encapsulation (near 100%).
    • All formulations showed good in vitro floating behavior.
    • Drug release rate was influenced by drug loading, polymer amount, and polymer type (PMMA < EC < Eudragit RS), allowing for varied release patterns.

    Conclusions:

    • The developed floating microparticles are suitable for gastroretentive drug delivery.
    • Formulation parameters, particularly polymer type and amount, significantly control drug release kinetics.
    • This novel system demonstrates potential for optimizing oral drug delivery with tunable release characteristics.