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[MR imaging of pancreatic lesions with Mn-DPDP. A histopathologic correlation]
M Dobritz1, F A Fellner, U Baum
1Institut für Diagnostische Radiologie, Friedrich-Alexander Universität Erlangen, Nürnberg, Germany.
Purpose:
To examine the diagnostic accuracy of pancreatic lesions using mangafodipir-trisodium (Mn-DPDP) enhanced MR imaging. The imaging results were correlated with the histopathological results.
Material And Methods:
40 patients with suspicion of pancreatic carcinoma were examined with MRI before and after i. v. administration of Mn-DPDP (Philips Gyroscan ACS NT 1.5 T, phased array body-coil: TSE T 2 with and without SPIR, TR 2000 ms, TE 120ms; FFE T 1 breathhold, TR 115 ms, TE 4.6 ms; MRCP, TR 6000 ms, TE 1200 ms; Teslascan i. v. 5 micromol Mn/kg; FFE T 1 breathhold SPIR, TR 140 ms, TE 4,6 ms). Two observers evaluated in consensus the number and characteristics of focal pancreatic lesions. The MR findings were correlated with histopathological findings retrospectively.
Results:
The following lesions were found: adenocarcinoma (19), pancreatitis (8), adenocarcinoma within pancreatitis (3), insulinoma (2), hematoma (1), papillitis stenosans (1), signet ring cell carcinoma (1), metastasis of rectal carcinoma (1), papillary mesothelioma (1). In three patients there was no pathological finding. Mn-DPDP enhanced MRI showed a sensitivity of 100 % and a specificity of 56 %.
Conclusion:
Mn-DPDP enhanced MRI in conjunction with MRCP showed a high sensitivity for the detection of pancreatic lesions. However, the specificity is low, thus recommending Mn-DPDP enhanced MRI only as a complementary imaging method.
Insights
Mangafodipir-trisodium (Mn-DPDP) enhanced MRI shows high sensitivity for detecting pancreatic lesions but has low specificity. This method is recommended as a complementary diagnostic tool.
Area of Science:
- Radiology
- Oncology
- Gastroenterology
Context:
- Pancreatic cancer diagnosis relies heavily on imaging.
- Accurate characterization of pancreatic lesions is crucial for patient management.
- Mangafodipir-trisodium (Mn-DPDP) is a contrast agent used in MRI.
Purpose:
- To evaluate the diagnostic accuracy of Mn-DPDP enhanced MRI for pancreatic lesions.
- To correlate MRI findings with histopathological results.
Summary:
- 40 patients with suspected pancreatic carcinoma underwent MRI with Mn-DPDP.
- Adenocarcinoma, pancreatitis, and other lesions were identified.
- Mn-DPDP enhanced MRI demonstrated 100% sensitivity and 56% specificity.
Impact:
- Mn-DPDP enhanced MRI, combined with MRCP, offers high sensitivity for pancreatic lesion detection.
- The low specificity suggests its use as an adjunctive imaging technique.
- Further research may refine the role of Mn-DPDP in pancreatic imaging.