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Cell response to AcrySof intraocular lenses in an Indian population
Abhay R Vasavada1, Lajja R Shastri, Shetal M Raj
1Iladevi Cataract & IOL Research Centre, Ahmedabad, India. shailad1@sancharnet.in
Journal of Cataract and Refractive Surgery
|July 11, 2002
Summary
Cell deposits on AcrySof intraocular lenses (IOLs) were evaluated in an Indian population. The study found a low incidence and severity of cell deposits, with all types disappearing within 12 months, indicating good biocompatibility.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Cell Biology
Background:
- Cataract surgery is a common procedure worldwide.
- Intraocular lenses (IOLs) are implanted to restore vision after cataract removal.
- AcrySof IOLs are widely used, and their cytological response requires evaluation.
Purpose of the Study:
- To assess the cytological response to AcrySof IOLs in an Indian population.
- To quantify the incidence, progression, and severity of cell deposits on IOLs.
- To determine the fate and resolution of these cell deposits post-surgery.
Main Methods:
- A prospective clinical study involving 64 patients undergoing phacoemulsification and AcrySof IOL implantation.
- Postoperative follow-up at 1 week and 1, 3, 6, 12, and 15 months.
- Slit-lamp biomicroscopy with specular reflex to record cell deposit characteristics.
Main Results:
- The highest incidence of small cell deposits was 18.7%, resolving within 6 months.
- Large and giant cell deposits had a highest incidence of 23.4% and 6.2% respectively, resolving within 12-15 months.
- No IOLs showed cell deposits at the final follow-up (mean 14 months).
Conclusions:
- AcrySof IOLs demonstrated a low incidence and severity of cell deposits in the Indian population.
- All observed cell types, including giant cells, resolved within one year.
- These findings suggest good biocompatibility of AcrySof IOLs and appropriate surgical techniques.
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