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The compositional evolution of the murid genome.

Nick G C Smith1, Adam Eyre-Walker

  • 1Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvägen 18D, SE-752 36 Uppsala, Sweden. nick.smith@ebc.uu.se

Journal of Molecular Evolution
|July 11, 2002
PubMed
Summary

The murid shift, a unique characteristic of murid rodents

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Area of Science:

  • Genomics
  • Evolutionary Biology
  • Mammalian Genetics

Background:

  • Murid rodents exhibit reduced isochore base composition variation compared to other mammals, termed the murid shift.
  • The evolutionary mechanisms and ongoing nature of this compositional difference remain incompletely understood.

Purpose of the Study:

  • To determine if the murid shift is an active, ongoing evolutionary process.
  • To investigate the roles of selection and biased gene conversion in shaping present-day mouse genome base composition.

Main Methods:

  • Estimation of ancestral base composition for protein-coding genes in murid rodents.
  • Analysis of non-genic polymorphism data to assess mutation bias effects.
  • Comparison of patterns derived from polymorphism and divergence data.

Main Results:

  • Estimates of ancestral base composition confirm the murid shift is an ongoing evolutionary event.
  • Non-genic polymorphism data do not provide evidence against mutation bias as the sole driver of base composition.
  • Discrepancies between polymorphism and divergence data patterns suggest potential for two distinct murid shifts.

Conclusions:

  • The murid shift is an ongoing evolutionary phenomenon in murid rodents.
  • While mutation bias may play a role, differing patterns suggest complex evolutionary forces, possibly including multiple shifts, are at play.

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