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Related Experiment Videos

Atom transfer radical cyclisation reactions mediated by copper complexes.

Andrew J Clark1

  • 1Chemistry Department, University of Warwick, Coventry, UK CV4 7AL.

Chemical Society Reviews
|July 12, 2002
PubMed
Summary
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Recent advances in copper complexes enable atom transfer radical cyclisation (ATRC) reactions at room temperature. This method efficiently synthesizes diverse ring sizes and shows potential for industrial applications.

Area of Science:

  • Organic Chemistry
  • Catalysis
  • Synthetic Methodology

Background:

  • Atom transfer radical cyclisation (ATRC) is a powerful synthetic tool.
  • Copper complexes are increasingly utilized as catalysts in ATRC reactions.
  • Developing efficient and versatile ATRC methods is crucial for organic synthesis.

Purpose of the Study:

  • To review recent advancements in copper-catalyzed ATRC reactions.
  • To highlight the development of novel activated copper complexes.
  • To explore the application of these complexes in synthesizing various ring sizes.

Main Methods:

  • Utilizing newly designed activated copper complexes.
  • Mediating cyclisation of tri-, di-, and mono-halo substrates.
  • Employing reactions at ambient temperatures.

Related Experiment Videos

  • Investigating tandem and radical-polar crossover reactions.

    • Main Results:

    • Successful mediation of ATRC reactions using activated copper complexes.
    • Efficient synthesis of rings ranging from 4 to 18 members.
    • Demonstration of tandem and radical-polar crossover reactions.
    • Development of solid-supported and perfluorous copper complexes.

    Conclusions:

    • Activated copper complexes offer efficient ATRC for diverse ring synthesis.
    • The methodology is effective at ambient temperatures.
    • Novel complexes, including solid-supported and perfluorous variants, enhance applicability.
    • This approach holds promise for industrial-scale synthesis of cyclic compounds.