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Updated: Aug 8, 2026

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Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
Published on: October 2, 2018
The total synthesis of alkaloids (-)-histrionicotoxin 259A, 285C and 285E
Catherine J Smith1, Andrew B Holmes, Neil J Press
1Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
Abstract:
The first total syntheses of three "unsymmetrical" (i.e. different terminal groups in the side chains) members of the histrionicotoxin family of alkaloids have been accomplished via stepwise introduction of the two side chain moieties onto a common tricyclic core.
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