Related Experiment Videos
[Dependence of galodif pharmacokinetics on duration of its administration]
E V Kanov1, T P Novozheeva, A S Saratikov
1Institute of Psychological Health, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, Sosnovyi Bor, Tomsk, 634014 Russia.
Eksperimental'Naia I Klinicheskaia Farmakologiia
|July 12, 2002
Abstract:
Pharmacokinetics of the new antiepileptic drug galodif was experimentally studied on rats. A single administration of the anticonvulsant is followed by slow elimination. A five-day administration leads to a significant acceleration of the drug elimination due to activation of the cytochrome P-450 dependent monooxygenase system of liver. After a 14-day administration, the elimination rate decreases as compared to that for the five-day treatment, while being still higher than in the case of single administration.