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Related Experiment Videos

Plasma adsorption in critical care.

Kwang-Seok Yang1, Kazuo Kenpe, Ken Yamaji

  • 1Department of Internal Medicine and Rheumatology, Juntendo University, Tokyo, Japan.

Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis
|July 12, 2002
PubMed
Summary

Immunoadsorption plasmapheresis (IAPP) offers advantages over plasma exchange (PE) and double filtration plasmapheresis (DFPP) by avoiding replacement fluids. Developing new adsorption therapies could reduce mortality in critically ill patients.

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Area of Science:

  • Critical Care Medicine
  • Renal Replacement Therapies

Background:

  • Plasmapheresis therapies, including plasma exchange (PE), double filtration plasmapheresis (DFPP), and immunoadsorption plasmapheresis (IAPP), are vital in critical care.
  • PE and DFPP non-selectively remove plasma components, necessitating replacement fluids like fresh frozen plasma or albumin, which carry risks of infection and allergic reactions.

Purpose of the Study:

  • To evaluate the advantages of immunoadsorption plasmapheresis (IAPP) over traditional plasmapheresis methods.
  • To highlight the potential of novel adsorption therapies in improving outcomes for critically ill patients.

Main Methods:

  • Comparison of IAPP with PE and DFPP, focusing on the requirement for replacement fluids.
  • Review of existing adsorbent column technologies for IAPP in treating critical illnesses.

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Main Results:

  • IAPP eliminates the need for replacement fluids, unlike PE and DFPP, thereby avoiding associated risks.
  • While IAPP has shown promise in treating various critical illnesses, its application is limited by the availability of specific adsorbent columns.

Conclusions:

  • Immunoadsorption plasmapheresis (IAPP) presents a superior alternative to PE and DFPP due to the absence of replacement fluid requirements.
  • Further development of new adsorption therapies is crucial for potentially decreasing the high mortality and morbidity rates observed in critically ill patients.