Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Picornavirus-receptor interactions.

Michael G Rossmann1, Yongning He, Richard J Kuhn

  • 1Department of Biological Sciences, Purdue University, West Lafayette, IN 47907-1392, USA. mgr@indiana.bio.purdue.edu

Trends in Microbiology
|July 12, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A distinct E dimer epitope underlies selective recognition by a protective human West Nile virus antibody.

EMBO reports·2026
Same author

Asymmetric structural transitions in the icosahedral organization of Eastern equine encephalitis virus.

Nature communications·2026
Same author

Efficacy and safety of subthreshold micropulse laser for chronic central serous chorioretinopathy: a systematic review and meta-analysis.

Frontiers in medicine·2026
Same author

Macrophage-rich niches regulate T cell dynamics at the liver invasive margin during gallbladder cancer progression.

The Journal of clinical investigation·2026
Same author

In situ structures of the portal-neck-tail complex of bacteriophage T4 inform a viral genome positioning mechanism.

Nature communications·2026
Same author

Corrigendum to "Meeting Report: The 3<sup>rd</sup> international conference of the World Society for Virology (WSV 2025) - The Virosphere of Our Cellular World".

Virology·2026
Same journal

Environmental microbes as modulators of plant volatile landscapes: Implications for plant-insect chemical communication.

Trends in microbiology·2026
Same journal

Beyond AMGs: Phage-encoded transcription and sigma factors as understudied virocell reprogramming tools.

Trends in microbiology·2026
Same journal

Cronobacter spp.

Trends in microbiology·2026
Same journal

Anaerobic lignin deconstruction: A game changer for lignocellulosic biorefineries.

Trends in microbiology·2026
Same journal

Critical role of the inflammatory rheostat in influenza-associated pulmonary aspergillosis.

Trends in microbiology·2026
Same journal

Structure-based prokaryotic transcription shapes adaptation and host-invader interplay.

Trends in microbiology·2026
See all related articles

Picornaviruses utilize immunoglobulin superfamily (IgSF) cell-surface receptors for entry. Rhino- and enteroviruses bind within a viral canyon, triggering uncoating, while other picornaviruses binding outside IgSF receptors do not destabilize the virus.

Area of Science:

  • Virology
  • Molecular and Cellular Biology

Background:

  • Picornaviruses are a family of viruses that cause various human and animal diseases.
  • Many picornaviruses employ cell-surface molecules from the immunoglobulin superfamily (IgSF) as cellular receptors.
  • These IgSF receptors typically feature tandem Ig-like domains, with the N-terminal domain mediating virus interaction.

Purpose of the Study:

  • To investigate the distinct mechanisms of picornavirus entry mediated by different classes of cellular receptors.
  • To differentiate the interaction modes between picornaviruses and IgSF receptors versus non-IgSF receptors.

Main Methods:

  • Analysis of viral-receptor interactions based on structural and functional data.
  • Comparison of binding sites and subsequent effects on viral stability for different picornavirus-receptor complexes.

Related Experiment Videos

Main Results:

  • Rhino- and enteroviruses, common picornaviruses, bind to IgSF receptors via a 'canyon' on the viral surface.
  • This canyon-mediated binding leads to viral destabilization and initiates the uncoating process.
  • Picornaviruses using non-IgSF receptors bind outside the viral canyon, and this interaction does not induce viral instability.

Conclusions:

  • The mode of picornavirus binding to cellular receptors dictates the viral entry pathway.
  • IgSF receptor engagement via a viral canyon is crucial for initiating uncoating in certain picornaviruses.
  • Non-IgSF receptors provide an alternative, non-destabilizing interaction point for picornavirus entry.