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QSAR studies on biological activity of piritrexim analogues against pc DHFR
Vijay K Agrawal1, Rashmi Sohgaura, Padmakar V Khadikar
1Computer and QSAR Laboratories, A.P.S. University, Rewa-486003, India.
Bioorganic & Medicinal Chemistry
|July 12, 2002
Abstract:
Quantitative structure-activity relationship (QSAR) studies for 2,6-substituted 2,4-diaminopyrido[3,2-d] pyrimidine analogues of piritrexim (PTX) as inhibitors of dihydrofolate reductase (DHFR) are now made using topological indices. The results have shown that best models are obtained by multiparametric analysis. The predictive potential of the model is discussed on the basis of a cross-validation method.