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Does PTH have a direct effect on intestine?
1Department of Nutrition and Food Sciences and the Biotechnology Center Utah State University, Logan, Utah 84322-8700, USA. nemere@cc.usu.edu
Journal of Cellular Biochemistry
|July 12, 2002
Summary
Parathyroid hormone (PTH) directly influences calcium and phosphate absorption in the intestine, challenging the long-held belief that its effects are solely mediated by vitamin D. This finding has significant implications for understanding mineral metabolism.
Area of Science:
- Endocrinology
- Gastroenterology
- Mineral Metabolism
Background:
- Established dogma posits parathyroid hormone (PTH) indirectly affects intestinal calcium and phosphate absorption via vitamin D synthesis.
- Emerging evidence suggests a potential direct role for PTH in intestinal mineral absorption.
Purpose of the Study:
- To review evidence supporting a direct effect of PTH on the intestine.
- To explore biological and biochemical evidence, as well as intestinal PTH receptors.
Main Methods:
- Literature review of studies investigating PTH's intestinal effects.
- Analysis of data on biological and biochemical responses.
- Examination of evidence for intestinal PTH receptor presence.
Main Results:
- Evidence suggests PTH has direct biological and biochemical effects on the intestine.
- Intestinal receptors for PTH have been identified, supporting a direct interaction.
Conclusions:
- The traditional view of PTH's indirect intestinal action needs re-evaluation.
- Direct PTH effects on the intestine have significant implications for biomedical research and mineral metabolism.
- Further research is warranted to fully elucidate the mechanisms and consequences of direct intestinal PTH signaling.