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Notoginsenoside R1 Alleviates Macrophage Inflammatory Responses via Modulating the JAK1/STAT3 Pathway
Chengjie Wu1,2, Shuting Hou3, Meizhi Liu1,2
1Shaoxing People's Hospital, Shaoxing, China.
Journal of Cellular Biochemistry
|July 29, 2026
Summary
Notoginsenoside R1 (NR1) from Panax notoginseng balances macrophage polarization via the JAK1/STAT3 pathway, reducing inflammation and potentially treating atherosclerosis.
Area of Science:
- Pharmacology
- Immunology
- Cardiovascular Research
Background:
- Atherosclerosis involves macrophage polarization.
- Panax notoginseng component Notoginsenoside R1 (NR1) shows potential anti-atherosclerotic effects.
- The JAK1/STAT3 pathway is implicated in macrophage function.
Purpose of the Study:
- Investigate NR1's mechanism against atherosclerosis.
- Determine NR1's effect on macrophage M1/M2 polarization.
- Elucidate NR1's role in the JAK1/STAT3 pathway.
Main Methods:
- Established M1, M2, and ox-LDL-induced macrophage models.
- Treated models with varying concentrations of NR1.
- Analyzed macrophage polarization, ox-LDL phagocytosis, lipid accumulation, and mitochondrial function.
Main Results:
- NR1 suppressed M1 polarization and promoted M2 polarization.
- NR1 inhibited ox-LDL uptake and reduced lipid accumulation.
- NR1 improved mitochondrial function and inhibited the JAK1/STAT3 pathway.
Conclusions:
- NR1 modulates macrophage polarization through the JAK1/STAT3 pathway.
- NR1 exhibits anti-atherosclerotic effects by reducing inflammation.
- NR1 is a potential therapeutic agent for atherosclerosis.
