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Human platelet aggregation inhibitors from thyme (Thymus vulgaris L.)
Kenji Okazaki1, Kazuyoshi Kawazoe, Yoshihisa Takaishi
1Kagawa Prefectural Fermentation and Food Experimental Station, 1351-1 Nouma Uchinomi-cho, Souzu-gun, Kagawa 761-4421, Japan.
Phytotherapy Research : PTR
|July 12, 2002
Abstract:
Two antiaggregant compounds, thymol (compound 1) and 3,4,3',4'-tetrahydroxy-5,5'-diisopropyl-2,2'-dimethylbiphenyl (compound 2) were isolated from the leaves of thyme (Thymus vulgaris L.). The structures were determined by (1)H-, (13)C-NMR and mass spectra (MS) studies. These compounds inhibited platelet aggregation induced by collagen, ADP, arachidonic acid (AA) and thrombin except that compound 2 did not inhibit platelet aggregation induced by thrombin.