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Related Experiment Videos

Thyroid calcification and its association with thyroid carcinoma.

Mark L C Khoo1, Sylvia L Asa, Ian J Witterick

  • 1Department of Otolaryngology, Mount Sinai Hospital, 600 University Avenue, Suite 401, Toronto, Ontario M5G 1X5, Canada. markkhoolc@yahoo.com

Head & Neck
|July 12, 2002
PubMed
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Thyroid calcifications in nodules detected by ultrasound significantly increase the risk of malignancy. Surgery is recommended for solitary thyroid nodules with calcification, even if fine-needle aspiration is benign.

Area of Science:

  • Endocrinology
  • Oncology
  • Radiology

Background:

  • Intrathyroidal calcification is often overlooked on ultrasonography.
  • Previous observations suggest a higher malignancy rate in calcified thyroid nodules.

Purpose of the Study:

  • To evaluate the association between intrathyroidal calcification and thyroid carcinoma.
  • To determine the risk of malignancy in thyroid nodules with calcification.

Main Methods:

  • Retrospective review of 462 thyroid surgery patients (1995-1999).
  • Analysis of preoperative ultrasonography findings, including intrathyroidal calcification.
  • Histopathologic examination for diagnosis.

Main Results:

  • Of 49 patients with calcification on ultrasound, 59.2% had thyroid carcinoma.

Related Experiment Videos

  • In solitary thyroid lesions with calcification, 75.7% were malignant.
  • Fine-needle aspiration cytology was benign in 24.1% of malignant cases.

    • Conclusions:

    • Calcification in a solitary thyroid nodule indicates a high risk of malignancy.
    • Surgical intervention is advised for solitary thyroid nodules with calcification, irrespective of fine-needle aspiration results.