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A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Management of Merkel cell carcinoma
T A Plunkett1, R Subrumanian, M D Leslie
1Guy's, King's and St Thomas' Cancer Centre, Guy's Hospital, London SE1 9RT, UK. plunkett@icrf.icnet.uk
Expert Review of Anticancer Therapy
|July 13, 2002
Summary
Merkel cell carcinoma, a rare but highly malignant skin cancer, requires appropriate treatment. This review summarizes literature to guide clinicians in managing this challenging diagnosis due to a lack of clinical trials.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Merkel cell carcinoma (MCC) is an uncommon but highly aggressive primary skin cancer.
- MCC has a significant potential for metastasis and recurrence.
- Effective management strategies are crucial due to its poor prognosis.
Purpose of the Study:
- To review the current literature on Merkel cell carcinoma.
- To provide guidance for clinicians on the diagnosis and management of MCC.
- To summarize treatment options and prognostic factors for MCC.
Main Methods:
- Literature search of relevant databases (e.g., PubMed, Embase).
- Review of studies focusing on epidemiology, diagnosis, staging, and treatment of MCC.
- Synthesis of evidence regarding surgical, radiation, and systemic therapies.
Main Results:
- No randomized controlled trials are available for MCC treatment.
- Treatment decisions often rely on expert opinion and case series.
- Multidisciplinary approaches are generally recommended.
Conclusions:
- Merkel cell carcinoma necessitates prompt and appropriate management.
- Treatment strategies should be individualized based on stage and patient factors.
- Further research, including clinical trials, is needed to establish evidence-based guidelines.
