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Related Experiment Video

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Direct Mouse Trauma/Burn Model of Heterotopic Ossification

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Published on: August 6, 2015

Button osteoma: its etiology and pathophysiology.

Vered Eshed¹, Bruce Latimer, Charles M Greenwald

¹Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

American Journal of Physical Anthropology

|July 13, 2002

Summary

This summary is machine-generated.

Button lesions (BtL), a common cranial bony overgrowth, appear frequently in both ancient and modern human populations across all demographics. Their structure suggests an evolutionary origin rather than a typical bone tumor.

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Area of Science:

Paleoanthropology
Skeletal Biology
Histopathology

Background:

Button lesions (BtL) are circumscribed bony overgrowths on the cranial vault.
Previous understanding of BtL as osteomas or exostoses is questioned.
The anthropological and evolutionary significance of BtL requires further investigation.

Purpose of the Study:

To investigate the histology, location, and population distribution of button lesions (BtL).
To analyze the anthropological implications of BtL frequency and characteristics.
To determine if BtL has an evolutionary background.

Main Methods:

Microscopic examination of BtL histology.
Analysis of BtL location on human and nonhuman primate skulls.
Statistical analysis of BtL prevalence across different populations (age, race, sex) and time periods.

Main Results:

BtL consists of dense, poorly vascularized lamellated bone with few osteocytes.
BtL frequency is high and consistent (37.6%-41.1%) in modern and archaeological human populations, independent of sex and race, and correlates with age.
BtL is rare in nonhuman primates, with most human skulls exhibiting single lesions predominantly on the parietal bones.

Conclusions:

The demographic characteristics and histological structure of BtL suggest it is a hamartoma with an evolutionary background.
BtL prevalence indicates it is a common phenomenon in human evolution.
Further research into the developmental and evolutionary pathways of BtL is warranted.