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Theory of sequence effects on DNA translocation through proteins and nanopores
1Polymer Science and Engineering, University of Massachusetts, Amherst, MA, USA. muthu@rati.pse.umass.edu
Electrophoresis
|July 13, 2002
Abstract:
A general formula for the sequence effects on the average translocation time of a polymer passing through a narrow hole under a chemical potential gradient is provided. The utility of the general expression is illustrated by considering the diblock sequence of a polymer with two kinds of monomers. The experimental conditions required for sufficient discrimination of various sequences are addressed.