[Quality control of analyses and automation]

Area of Science:

• Clinical Biochemistry
• Laboratory Medicine
• Analytical Chemistry

Background:

• Multichannel analyzers are increasingly common in modern biochemistry laboratories.
• The widespread adoption necessitates stringent quality control (QC) programs.
• Ensuring the accuracy and reliability of diagnostic results is paramount.

Purpose of the Study:

• To evaluate the effectiveness of various quality control strategies for multichannel analyzers.
• To assess the utility of traditional QC methods alongside automated approaches.
• To provide recommendations for optimal QC implementation in clinical settings.

Main Methods:

• A three-year experimental study was conducted comparing a computer-connected Autochemist (24 channels) and an unconnected Technicon SMA 12/60.
• Traditional quality control using lyophilized control serums was assessed.
• Automated calibration and statistical controls on pooled human serum and patient results were implemented and analyzed.

Main Results:

• Traditional quality control using lyophilized serums remains necessary and valuable, particularly at a regional level.
• Automated calibration demonstrated effectiveness in maintaining instrument performance.
• Statistical controls on pooled serum and patient data provided reliable insights into analytical performance over time.

Conclusions:

• A comprehensive quality control program integrating traditional and automated methods is crucial for multichannel analyzers.
• Automated calibration and statistical process control are valuable adjuncts to traditional QC methods.
• Effective QC strategies ensure the accuracy and reliability of biochemical analyses, supporting clinical decision-making.